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ORIGINAL ARTICLE
Year : 2015  |  Volume : 2  |  Issue : 1  |  Page : 11-14

A study to assess the pattern of drug resistance and its causes among patients registered as retreatment cases of Tuberculosis in a tertiary care center of central India


1 Department of General Medicine, Sri Aurobindo Medical College, Indore, Madhya Pradesh, India
2 Department of Respiratory Medicine, Sri Aurobindo Medical College, Indore, Madhya Pradesh, India

Correspondence Address:
Abhishek Singhai
Department of General Medicine, Sri Aurobindo Medical College, Indore - 453 111, Madhya Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2148-7731.145797

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Context: Tuberculosis is a major public health priority in the world with 8-10 million new cases added every year. Aims: To obtain information about drug resistance pattern of patients registered as re-treatment cases and its causes along with source of previous drug exposure. Settings and Design: This is a prospective study done at a tertiary care center. Materials and Methods: A total of 100 patients of re-treatment cases who gave oral informed consent were registered as subjects. Results: Drug resistance was identified as 25% mono drug and 22% multidrug resistance among retreatment cases. Isoniazid (25%) was the most common drug against which drug resistance was identified. Conclusions: Multidrug resistance is a significant health problem. Majority of these patients were drug defaulters. Our study identifies drug intolerance, ignorance about advised treatment, early symptomatic relief as the predominant causes of defaulting.


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