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ORIGINAL ARTICLE
Year : 2015  |  Volume : 2  |  Issue : 2  |  Page : 31-36

Anti-hyperlipidemic activity of Crataeva nurvala Buch-Hum ethanolic extract fractions


1 Department of Pharmacognosy and Phytochemistry, Karnatak Lingayat Education University College of Pharmacy, Belgaum, Karnataka, India; Unit of Pharmaceutical Chemistry, Faculty of Pharmacy, Asian Institute of Medicine, Science and Technology University, Kedah, Malaysia
2 Department of Pharmacognosy and Phytochemistry, Karnatak Lingayat Education University College of Pharmacy, Belgaum, Karnataka, India

Correspondence Address:
Dr. Mukesh Singh Sikarwar
Faculty of Pharmacy, Asian Institute of Medicine, Science and Technolog University, Semeling - 08100 Bedong, Kedah, Malaysia

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2148-7731.152114

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Aim: This study investigates the anti-hyperlipidemic effect of Crataeva nurvala Buch-Hum ethanolic extract fractions in triton and atherogenic diet-induced hyperlipidemic rats. Methods: Oral administrations of 500 mg/kg body weight of various fractions of selected plant were evaluated for possible hyperlipidemic activity in triton and atherogenic diet-induced hyperlipidemic rats for duration of 48 hours and 14 days, respectively. A comparative assessment was also made between the actions of selected drug with known anti-hyperlipidemic drug simvastatin. The outcomes of the study were expressed as mean± standard error (SE) and data was evaluated by using analysis of variance (ANOVA), followed by Dunnett's t-test for multiple comparisons. Results and Discussion: Ethanolic extract Ethyl acetate fraction of Crataeva nurvala stem bark 500 mg/kg body weight on oral administration exhibited a significant reduction (P < 0.01) in serum lipid parameters like triglycerides, total cholesterol, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and increase in high-density lipoprotein (HDL) in hyperlipidemic rats as compared with hyperlipidemic control in both models. Conclusion: Our results demonstrated that Crataeva nurvala Buch-Hum ethanol extract ethyl acetate fractions possessed significant anti-hyperlipidemic activity.


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